Fibrinogen is a protein synthesized by the liver that plays a crucial role in blood clotting, serving as the precursor to fibrin. It is a vital biological factor in the thrombosis and hemostasis system. Changes in plasma fibrinogen levels are associated not only with coagulation disorders and hemorrhagic diseases but also with conditions like DIC (disseminated intravascular coagulation) and primary hyperfibrinolysis. Low fibrinogen levels are often caused by liver damage due to hepatitis, cirrhosis, or liver cancer, which impairs the liver's ability to produce fibrinogen. Additionally, in cases of disseminated intravascular coagulation, widespread aggregation of fibrinogen leads to increased consumption and a subsequent reduction in plasma fibrinogen levels. Moreover, in primary hyperfibrinolysis, the enhanced activity of fibrinolysin accelerates the breakdown of fibrinogen, resulting in lower fibrinogen levels.