The primary cause of scleroderma esophagus is systemic scleroderma, a condition that affects multiple systems and organs throughout the body. The main pathological changes involve widespread vascular lesions, collagen proliferation, and fibrosis in the affected tissues. These changes also occur in the esophagus, leading to a series of complications.
Esophageal damage can manifest in the early stages of scleroderma and is one of the most common visceral complications. Dysfunction in the lower esophagus can cause difficulty swallowing, and damage to the sphincter can lead to reflux esophagitis. Over time, this can result in esophageal stricture, presenting a range of clinical symptoms.